| AMG S 65 V12 • 630 HP • AMG SPEEDSHIFT PLUS | 630 HP | 4.3 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| AMG S 63 V8 • 585 HP • 4MATIC AMG SPEEDSHIFT MCT | 585 HP | 4 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 600 V12 • 530 HP • 7G-TRONIC PLUS | 530 HP | 4.6 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 455 HP • 4MATIC 7G-TRONIC PLUS | 455 HP | 4.8 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 455 HP • 9G-TRONIC | 455 HP | 4.8 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 455 HP • 7G-TRONIC PLUS | 455 HP | 4.8 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 455 HP • 4MATIC 9G-TRONIC | 455 HP | 4.8 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 500e V6 • 442 HP • Plug-in Hybrid 7G-TRONIC PLUS | 442 HP | 5.2 sec | 250 km/h | 7-speed automatic | Petrol / electricity |
| S 400 • 333 HP • HYBRID G-TRONIC | 333 HP | 6.8 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 320 V6 • 272 HP • 7G-TRONIC PLUS | 272 HP | 7.1 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 350 BlueTEC V6 • 258 HP • 4MATIC 7G-TRONIC PLUS | 258 HP | 6.8 sec | 250 km/h | 7-speed automatic | Diesel |
| S 350d V6 • 258 HP • 4MATIC 9G-TRONIC | 258 HP | 6.5 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350d V6 • 258 HP • 9G-TRONIC | 258 HP | 6.5 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350 BlueTEC V6 • 258 HP • 7G-TRONIC PLUS | 258 HP | 6.8 sec | 250 km/h | 7-speed automatic | Diesel |
| S 300 BlueTEC • 231 HP • HYBRID G-TRONIC | 231 HP | 7.6 sec | 240 km/h | 7-speed automatic | Diesel |
